Weight-loss: Are injections the reply to tackling weight problems?

Semaglutide Injection

You can’t escape the hype round weight-loss injections.

Social media is filled with before-and-after footage. They are the supply of untamed gossip about Hollywood stars, and now the UK’s National Health Service goes to pay for them.

You can perceive the attraction. Excess weight impacts our well being and results in stigma – and the mantra of “diet and exercise” has merely failed for most individuals.

But ought to we be calling semaglutide, the drug in query, a “miracle” or “skinny jab” when some docs suppose it’s as controversial as remedies get? Does the hype match the truth? Or are we failing to sort out the causes of weight problems and simply consigning individuals to a lifetime of medicine?

Short Presentational Grey Line

Jan, from Kent, was one of many first individuals on this planet to participate within the trials of semaglutide. It is offered as Wegovy for weight-loss and as Ozempic for diabetes, though some individuals have been shopping for this model to shed extra pounds.

We all know any individual like Jan, who has tried each weight loss plan, and he or she has been battling her waistline her entire life.

Semaglutide mimics a hormone that’s launched once we eat. It methods the mind into pondering we’re full and dials down urge for food so we eat much less.

Once Jan began having the injections, her relationship with meals was so transformational that she informed me it was both right down to the drug or “I’ve been abducted by aliens”.

For the primary time she may go into a restaurant, see some millionaire’s shortbread and never have her physique screaming, “I need one”.

Instead it was, “I don’t feel hungry… my body was saying you don’t want it, it wasn’t me using willpower,” she says.

The outcomes of semaglutide are simple – at the least for some time.

On common, individuals who have been overweight misplaced about 15% of their physique weight when taking semaglutide alongside wholesome way of life recommendation in a trial. Note this isn’t a “skinny jab” – 15% takes you from 20 stone right down to 17.

That examine confirmed the load got here off over the primary yr after which stabilised for the remaining three months of the trial. We have no idea what occurs when individuals take the drug for years.

Jan misplaced 28kg (greater than 4 stone). It meant she may lastly get pleasure from her 60th birthday current – a flight in a Tiger Moth aeroplane, having been over the utmost weight restrict earlier than. “I was flying in more ways than one, and boy did I enjoy it.”

Jan Took Part In The Trial

The outcomes appear extra compelling than your typical weight loss plan, which regularly begins effectively however then your depleted fats shops sign to the mind to hunt meals. That is why diets in the end fail.

“More than 90% of people tend to end up back at the weight they were before they started on their dietary journey,” says Prof Sir Stephen O’Rahilly, the director of the Medical Research Council’s Metabolic Diseases Unit.

He sees these medicine because the “beginning of an exciting era” the place medicine may also help individuals who have “struggled for a long time” with weight that’s damaging their well being.

Jan’s trial concluded, and he or she was now not capable of take semaglutide. Without the drug her mind was now not being tricked into pondering she was full.

“I was quite upset because the weight was going back on,” she informed me – and he or she was “promising the world” to anyone who may give her the drug.

She tried different weight-loss injections, however in the end selected to have main surgical procedure and a gastric sleeve to scale back the scale of her abdomen, so she would really feel full quicker.

Jan has “no regrets” and nonetheless describes the drug because the “best thing that ever happened to me”.

The weight comes again

However, her expertise is much from distinctive and the load acquire after coming off semaglutide is swift. The greatest long-term knowledge we have now reveals individuals regain two-thirds of their misplaced weight inside two years of stopping.


“It’s a drug that seems to need to be kept taken in order to ensure that weight doesn’t return and that’s, for me, a big problem,” says Dr Margaret McCartney, a GP and champion of proof in medication.

The NHS is providing semaglutide for less than two years, which is how lengthy individuals can entry weight reduction clinics. Given the load acquire after coming off the drug, it’s honest to ask – what’s the level?

“It’s really pretty awful for many people who are wanting to lose weight, and have struggled usually for years. If you get something that ends up working for you, and then for the NHS to go and withdraw that again, it does seem to me to be a bit unfair,” says Dr McCartney.

There are, in fact, circumstances the place briefly losing a few pounds could also be useful. Some surgical procedures and coverings are solely provided to individuals beneath a set threshold, for instance.

It is a brand new drug and the long-term security is unknown. Side results embrace vomiting, fatigue and an infected pancreas.

Medical victory or societal failure?

Personally, I can’t determine whether or not we should always have fun that medication has produced such a drug, or whether it is really the alternative – that we have now failed so badly to sort out weight problems all through society that we now want medicine.

“Many of us have been wrestling with that,” says Naveed Sattar, professor of metabolic medication on the University of Glasgow.

He comes down on the aspect of pragmatism. Half the planet is projected to be chubby or overweight by 2035, and extra weight is linked to sort 2 diabetes, coronary heart illness and a few cancers. Cheap energy have “fed into human biology of being tempted by food and overeating”, he says.

And many NHS sufferers “have four or five conditions as a result of their excess weight, and at the moment we pay lip service to it”, he says.

Meanwhile authorities weight problems insurance policies within the UK – 14 of them up to now three many years – haven’t turned the tide and that has largely been felt by the poorest individuals within the nation. There is a transparent hyperlink between deprivation and weight problems.

Dr McCartney argues we have to sort out how the world we reside in fuels weight problems relatively than “expecting” individuals to placed on weight “and then accept a medical intervention to treat it”.



Semaglutide is altering the panorama of weight problems – and options are on the way in which.

Prof O’Rahilly says that even when we clear up the societal causes of weight problems “there will be obese people and they will become ill”, so he thinks the medicine will move us to a world of treating weight problems “properly as a medical condition”.

But these medicine stay controversial – and we have now solely mentioned their use for enhancing well being.

Further issues are being raised in regards to the impression on individuals, typically younger ladies, who’re pressured to look a sure method when “beautiful” is usually equated to “thin”.

The function of superstar tradition, the provision of semaglutide privately by means of online-only consultations, and the impression on consuming issues are additionally fuelling questions.

Whatever you concentrate on semaglutide, the talk round this drug, and the hype, is clearly not going away.

Follow James on Twitter. Inside Health was produced by Erika Wright.

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